If you are looking for information on how to manage these files or find "free" save data, What is an epsxe000.mcr file?

Free Fix:

Simply delete the empty epsxe000.mcr file and let ePSXe create a new one using Method 1 or 2 above.

• Keep regular backups of memory card files.
• Use consistent ePSXe versions and plugin configurations.
• Store emulator and save files in user-writable directories.

Background on ePSXe

6. Security & Reliability Considerations